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Article

TherMos: Estimating protein-DNA binding energies from in vivo binding profiles.

Nucleic acids research - 1 Jun 2013

Sun Wenjie, Hu Xiaoming, Lim Michael H K, Ng Calista K L, Choo Siew Hua, Castro Diogo S, Drechsel Daniela, Guillemot François, Kolatkar Prasanna R, Jauch Ralf, Prabhakar Shyam

Abstract excerpt

Accurately characterizing transcription factor (TF)-DNA affinity is a central goal of regulatory genomics. Although thermodynamics provides the most natural language for describing the continuous range of TF-DNA affinity, traditional motif discovery algorithms focus instead on classification paradigms that aim to discriminate 'bound' and 'unbound' sequences. Moreover, these algorithms do not directly model the...

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Identifiers

PMID: 23595148
DOI: 10.1093/nar/gkt250
PMCID: PMC3675472

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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