Article

Combining transcription factor binding affinities with open-chromatin data for accurate gene expression prediction

2016-10-19

Abstract excerpt

The binding and contribution of transcription factors (TF) to cell specific gene expression is often deduced from open-chromatin measurements to avoid costly TF ChIP-seq assays. Thus, it is important to develop computational methods for accurate TF binding prediction in open-chromatin regions (OCRs). Here, we report a novel segmentation-based method, TEPIC, to predict TF binding by combining sets of OCRs with posi...

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Literature Corpus work: b1e18c35-5c09-56b7-908e-b8683958b42e
DOI: 10.1101/081935

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