Efficient study designs for test of genetic association using sibship data and unrelated cases and controls.

Abstract excerpt

Linkage mapping of complex diseases is often followed by association studies between phenotypes and marker genotypes through use of case-control or family-based designs. Given fixed genotyping resources, it is important to know which study designs are the most efficient. To address this problem, we extended the likelihood-based method of Li et al., which assesses whether there is linkage disequilibrium between a...

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