Use of parents, sibs, and unrelated controls for detection of associations between genetic markers and disease.

doi:10.1086/302094

Back to search

Article

Use of parents, sibs, and unrelated controls for detection of associations between genetic markers and disease.

American journal of human genetics - 1 Nov 1998

Schaid D J, Rowland C

Abstract excerpt

Detecting the association between genetic markers and complex diseases can be a critical first step toward identification of the genetic basis of disease. Misleading associations can be avoided by choosing as controls the parents of diseased cases, but the availability of parents often limits thi...

Topics

Female
Gene Frequency
Genetic Diseases, Inborn
Genetic Markers
Genotype
Humans
Male
Models, Genetic
Models, Statistical
Nuclear Family
Parents

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.