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Article

Use of parents, sibs, and unrelated controls for detection of associations between genetic markers and disease.

American journal of human genetics - 1 Nov 1998

Schaid D J, Rowland C

Abstract excerpt

Detecting the association between genetic markers and complex diseases can be a critical first step toward identification of the genetic basis of disease. Misleading associations can be avoided by choosing as controls the parents of diseased cases, but the availability of parents often limits this design to early-onset disease. Alternatively, sib controls offer a valid design. A general multivariate score...

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Identifiers

PMID: 9792877
DOI: 10.1086/302094
PMCID: PMC1377560

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Source receipt: pubmed, retrieved 7 Sept 2026.

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