Increasing the power and efficiency of disease-marker case-control association studies through use of allele-sharing information.

doi:10.1086/381652

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Article

Increasing the power and efficiency of disease-marker case-control association studies through use of allele-sharing information.

American journal of human genetics - 1 Mar 2004

Fingerlin Tasha E, Boehnke Michael, Abecasis Gonçalo R

Abstract excerpt

Case-control disease-marker association studies are often used in the search for variants that predispose to complex diseases. One approach to increasing the power of these studies is to enrich the case sample for individuals likely to be affected because of genetic factors. In this article, we c...

Topics

Alleles
Case-Control Studies
Data Interpretation, Statistical
Genetic Diseases, Inborn
Genetic Markers
Humans

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