Robust and Powerful Affected Sibpair Test for Rare Variant Association.

Abstract excerpt

Advances in DNA sequencing technology facilitate investigating the impact of rare variants on complex diseases. However, using a conventional case-control design, large samples are needed to capture enough rare variants to achieve sufficient power for testing the association between suspected loci and complex diseases. In such large samples, population stratification may easily cause spurious signals. One...

Topics

• Case-Control Studies
• Computer Simulation
• Gene Frequency
• Genetic Linkage
• Genetic Predisposition to Disease
• Genetic Variation
• Genotype
• Humans
• Matched-Pair Analysis
• Models, Genetic
• Models, Statistical