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Article

Robust and Powerful Affected Sibpair Test for Rare Variant Association.

Genetic epidemiology - 1 Jul 2015

Lin Keng-Han, Zöllner Sebastian

Abstract excerpt

Advances in DNA sequencing technology facilitate investigating the impact of rare variants on complex diseases. However, using a conventional case-control design, large samples are needed to capture enough rare variants to achieve sufficient power for testing the association between suspected loci and complex diseases. In such large samples, population stratification may easily cause spurious signals. One...

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PMID: 25966809
DOI: 10.1002/gepi.21903
PMCID: PMC4469535

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