Article
Drosophila cyfip regulates synaptic development and endocytosis by suppressing filamentous actin assembly.
PLoS genetics - 1 Apr 2013
Zhao Lu, Wang Dan, Wang Qifu, Rodal Avital A, Zhang Yong Q
Abstract excerpt
The formation of synapses and the proper construction of neural circuits depend on signaling pathways that regulate cytoskeletal structure and dynamics. After the mutual recognition of a growing axon and its target, multiple signaling pathways are activated that regulate cytoskeletal dynamics to determine the morphology and strength of the connection. By analyzing Drosophila mutations in the cytoplasmic FMRP...
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