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Article

MAN1 Restricts BMP Signaling During Synaptic Growth in Drosophila.

Cellular and molecular neurobiology - 1 Aug 2017

Laugks Ulrike, Hieke Marie, Wagner Nicole

Abstract excerpt

Bone morphogenic protein (BMP) signaling is crucial for coordinated synaptic growth and plasticity. Here, we show that the nuclear LEM-domain protein MAN1 is a negative regulator of synaptic growth at Drosophila larval and adult neuromuscular junctions (NMJs). Loss of MAN1 is associated with synaptic structural defects, including floating T-bars, membrane attachment defects, and accumulation of vesicles between...

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PMID: 27848060
DOI: 10.1007/s10571-016-0442-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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