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Article

ADF/Cofilin Controls Synaptic Actin Dynamics and Regulates Synaptic Vesicle Mobilization and Exocytosis.

Cerebral cortex (New York, N.Y. : 1991) - 1 Sept 2015

Wolf Michael, Zimmermann Anika-Maria, Görlich Andreas, Gurniak Christine B, Sassoè-Pognetto Marco, Friauf Eckhard, Witke Walter, Rust Marco B

Abstract excerpt

Actin is a regulator of synaptic vesicle mobilization and exocytosis, but little is known about the mechanisms that regulate actin at presynaptic terminals. Genetic data on LIMK1, a negative regulator of actin-depolymerizing proteins of the ADF/cofilin family, suggest a role for ADF/cofilin in presynaptic function. However, synapse physiology is fully preserved upon genetic ablation of ADF in mice, and n-cofilin...

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Identifiers

PMID: 24770705
DOI: 10.1093/cercor/bhu081

Genes

LIMK1

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