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Article

Highwire regulates synaptic growth in Drosophila.

Neuron - 1 May 2000

Wan H I, DiAntonio A, Fetter R D, Bergstrom K, Strauss R, Goodman C S

Abstract excerpt

The formation, stabilization, and growth of synaptic connections are dynamic and highly regulated processes. The glutamatergic neuromuscular junction (NMJ) in Drosophila grows new boutons and branches throughout larval development. A primary walking behavior screen followed by a secondary anatomical screen led to the identification of the highwire (hiw) gene. In hiw mutants, the specificity of motor axon...

Topics

Animals
Caenorhabditis elegans
Chromosome Mapping
Drosophila
Drosophila Proteins
Growth Cones
Humans
Molecular Sequence Data
Mutation
Nerve Tissue Proteins
Neuromuscular Junction
Peptide Fragments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Presynaptic Terminals

Sequence Homology, Amino Acid

Synapses

Tissue Distribution

Transcription, Genetic

Source

Identifiers

PMID: 10839352
DOI: 10.1016/s0896-6273(00)81166-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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