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Article

Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in Drosophila.

Neuron - 19 Feb 2004

Coyle Ian P, Koh Young-Ho, Lee Wyan-Ching Mimi, Slind Jessica, Fergestad Tim, Littleton J Troy, Ganetzky Barry

Abstract excerpt

We describe the isolation and characterization of nwk (nervous wreck), a temperature-sensitive paralytic mutant that causes excessive growth of larval neuromuscular junctions (NMJs), resulting in increased synaptic bouton number and branch formation. Ultrastructurally, mutant boutons have reduced size and fewer active zones, associated with a reduction in synaptic transmission. nwk encodes an FCH and SH3...

Topics

Adaptor Proteins, Vesicular Transport
Amino Acid Sequence
Animals
Base Sequence
Cell Differentiation
Chromosome Mapping
DNA, Complementary
Drosophila
Drosophila Proteins
Evolution, Molecular

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microfilament Proteins

Microscopy, Electron

Molecular Sequence Data

Mutation

Nerve Tissue Proteins

Neuromuscular Junction

Phylogeny

Protein Structure, Tertiary

Source

Identifiers

PMID: 14980202
DOI: 10.1016/s0896-6273(04)00016-9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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Nervous wreck, an SH3 adaptor protein that interacts with Wsp, regulates synaptic growth in Drosophila.PMID 14980202Read ↗

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