Article
Physical and genetic-interaction density reveals functional organization and informs significance cutoffs in genome-wide screens.
Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2013
Dittmar John C, Pierce Steven, Rothstein Rodney, Reid Robert J D
Abstract excerpt
Genome-wide experiments often measure quantitative differences between treated and untreated cells to identify affected strains. For these studies, statistical models are typically used to determine significance cutoffs. We developed a method termed "CLIK" (Cutoff Linked to Interaction Knowledge) that overlays biological knowledge from the interactome on screen results to derive a cutoff. The method takes...
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