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Article

Detection of functional protein domains by unbiased genome-wide forward genetic screening.

Scientific reports - 18 Apr 2018

Herzog Mareike, Puddu Fabio, Coates Julia, Geisler Nicola, Forment Josep V, Jackson Stephen P

Abstract excerpt

Establishing genetic and chemo-genetic interactions has played key roles in elucidating mechanisms by which certain chemicals perturb cellular functions. In contrast to gene disruption/depletion strategies to identify mechanisms of drug resistance, searching for point-mutational genetic suppressors that can identify separation- or gain-of-function mutations has been limited. Here, by demonstrating its utility in...

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Identifiers

PMID: 29670134
DOI: 10.1038/s41598-018-24400-4
PMCID: PMC5906580

Genes

PARP1

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