Article
A nucleosomal region important for ensuring proper interactions between the transcription elongation factor Spt16 and transcribed genes in Saccharomyces cerevisiae.
G3 (Bethesda, Md.) - 21 Jun 2013
Nguyen Hoai-Trang T, Wharton William, Harper Jennifer A, Dornhoffer James R, Duina Andrea A
Abstract excerpt
The highly conserved FACT (FAcilitates Chromatin Transactions) histone chaperone assists in the transcription elongation process first by facilitating the removal of histones in front of transcribing RNA polymerase II (Pol II) and then by contributing to nucleosome reassembly in the wake of Pol II passage. Whereas it is well established that FACT localizes across actively transcribed genes, the mechanisms that...
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