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Article

The yeast FACT complex has a role in transcriptional initiation.

Molecular and cellular biology - 1 Jul 2005

Biswas Debabrata, Yu Yaxin, Prall Matthew, Formosa Tim, Stillman David J

Abstract excerpt

A crucial step in eukaryotic transcriptional initiation is recognition of the promoter TATA by the TATA-binding protein (TBP), which then allows TFIIA and TFIIB to be recruited. However, nucleosomes block the interaction between TBP and DNA. We show that the yeast FACT complex (yFACT) promotes TBP binding to a TATA box in chromatin both in vivo and in vitro. The SPT16 gene encodes a subunit of yFACT, and we show...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Chromatin Immunoprecipitation

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Source

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Identifiers

PMID: 15987999
DOI: 10.1128/MCB.25.14.5812-5822.2005
PMCID: PMC1168812

Genes

TBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The yeast FACT complex has a role in transcriptional initiation.PMID 15987999Read ↗

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