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Article

Mutant versions of the S. cerevisiae transcription elongation factor Spt16 define regions of Spt16 that functionally interact with histone H3.

PloS one - 1 Jan 2011

Myers Catherine N, Berner Gary B, Holthoff Joseph H, Martinez-Fonts Kirby, Harper Jennifer A, Alford Sarah, Taylor Megan N, Duina Andrea A

Abstract excerpt

In eukaryotic cells, the highly conserved FACT (FAcilitates Chromatin Transcription) complex plays important roles in several chromatin-based processes including transcription initiation and elongation. During transcription elongation, the FACT complex interacts directly with nucleosomes to facilitate histone removal upon RNA polymerase II (Pol II) passage and assists in the reconstitution of nucleosomes...

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Identifiers

PMID: 21673966
DOI: 10.1371/journal.pone.0020847
PMCID: PMC3108975

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutant versions of the S. cerevisiae transcription elongation factor Spt16 define regions of Spt16 that functionally interact with histone H3.PMID 21673966Read ↗

A nucleosomal region important for ensuring proper interactions between the transcription elongation factor Spt16 and transcribed genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

New mutant versions of yeast FACT subunit Spt16 affect cell integrity.Semantic proximity Read ↗

Evidence that the localization of the elongation factor Spt16 across transcribed genes is dependent upon histone H3 integrity in Saccharomyces cerevisiae.Semantic proximity Read ↗

Domain organization of the yeast histone chaperone FACT: the conserved N-terminal domain of FACT subunit Spt16 mediates recovery from replication stress.Semantic proximity Read ↗

The chromatin-specific transcription elongation factor FACT comprises human SPT16 and SSRP1 proteins.Semantic proximity Read ↗

Charged residues on the side of the nucleosome contribute to normal Spt16-gene interactions in budding yeast.Semantic proximity Read ↗

The Histone Chaperone FACT Contributes to DNA Replication-Coupled Nucleosome Assembly.Semantic proximity Read ↗

Insight into the mechanism of nucleosome reorganization from histone mutants that suppress defects in the FACT histone chaperone.Semantic proximity Read ↗

FACT, the Bur kinase pathway, and the histone co-repressor HirC have overlapping nucleosome-related roles in yeast transcription elongation.Semantic proximity Read ↗

The FACT chromatin modulator: genetic and structure/function relationships.Semantic proximity Read ↗

The yeast FACT complex has a role in transcriptional initiation.Semantic proximity Read ↗

A systematic mutational analysis of a histone H3 residue in budding yeast provides insights into chromatin dynamics.Semantic proximity Read ↗

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