Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A systematic mutational analysis of a histone H3 residue in budding yeast provides insights into chromatin dynamics.

G3 (Bethesda, Md.) - 23 Feb 2015

Johnson Paige, Mitchell Virginia, McClure Kelsi, Kellems Martha, Marshall Sarah, Allison Mary K, Lindley Harrison, Nguyen Hoai-Trang T, Tackett Jessalyn E, Duina Andrea A

Abstract excerpt

In previous work using the Saccharomyces cerevisiae model system, a mutant version of histone H3-H3-L61W-was found to confer a variety of abnormal growth phenotypes and defects in specific aspects of the transcription process, including a pronounced alteration in the distribution pattern of the transcription elongation factor Spt16 across transcribed genes and promotion of cryptic transcription initiation within...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Chromatin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Histones

Share to Nucleosomes

Share to Phenotype

Share to Saccharomyces cerevisiae

Share to Saccharomyces cerevisiae Proteins

Share to Transcriptional Elongation Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 25711831
DOI: 10.1534/g3.115.017376
PMCID: PMC4426362

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A systematic mutational analysis of a histone H3 residue in budding yeast provides insights into chromatin dynamics.PMID 25711831Read ↗

Evidence that the localization of the elongation factor Spt16 across transcribed genes is dependent upon histone H3 integrity in Saccharomyces cerevisiae.Semantic proximity Read ↗

Dominant effects of the histone mutant H3-L61R on Spt16-gene interactions in budding yeast.Semantic proximity Read ↗

Mutant versions of the S. cerevisiae transcription elongation factor Spt16 define regions of Spt16 that functionally interact with histone H3.Semantic proximity Read ↗

A nucleosomal region important for ensuring proper interactions between the transcription elongation factor Spt16 and transcribed genes in Saccharomyces cerevisiae.Semantic proximity Read ↗

A Budding Yeast Model and Screen to Define the Functional Consequences of Oncogenic Histone Missense MutationsSemantic proximity Read ↗

Analysis of a mutant histone H3 that perturbs the association of Swi/Snf with chromatin.Semantic proximity Read ↗

Identification of histone mutants that are defective for transcription-coupled nucleosome occupancy.Semantic proximity Read ↗

A Saccharomyces cerevisiae model and screen to define the functional consequences of oncogenic histone missense mutations.Semantic proximity Read ↗

Analysis of Saccharomyces cerevisiae histone H3 mutants reveals the role of the alphaN helix in nucleosome function.Semantic proximity Read ↗

The FACT histone chaperone guides histone H4 into its nucleosomal conformation in Saccharomyces cerevisiae.Semantic proximity Read ↗

Sin mutations of histone H3: influence on nucleosome core structure and function.Semantic proximity Read ↗

Dispersed mutations in histone H3 that affect transcriptional repression and chromatin structure of the CHA1 promoter in Saccharomyces cerevisiae.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.