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Article

Insight into the mechanism of nucleosome reorganization from histone mutants that suppress defects in the FACT histone chaperone.

Genetics - 1 Aug 2011

McCullough Laura, Rawlins Robert, Olsen Aileen, Xin Hua, Stillman David J, Formosa Tim

Abstract excerpt

FACT (FAcilitates Chromatin Transcription/Transactions) plays a central role in transcription and replication in eukaryotes by both establishing and overcoming the repressive properties of chromatin. FACT promotes these opposing goals by interconverting nucleosomes between the canonical form and a more open reorganized form. In the forward direction, reorganization destabilizes nucleosomes, while the reverse...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21625001
DOI: 10.1534/genetics.111.128769
PMCID: PMC3176083

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Insight into the mechanism of nucleosome reorganization from histone mutants that suppress defects in the FACT histone chaperone.PMID 21625001Read ↗

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FACT and the reorganized nucleosome.Semantic proximity Read ↗

Domain organization of the yeast histone chaperone FACT: the conserved N-terminal domain of FACT subunit Spt16 mediates recovery from replication stress.Semantic proximity Read ↗

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