Article
FACT, the Bur kinase pathway, and the histone co-repressor HirC have overlapping nucleosome-related roles in yeast transcription elongation.
PloS one - 1 Jan 2011
Stevens Jennifer R, O'Donnell Allyson F, Perry Troy E, Benjamin Jeremy J R, Barnes Christine A, Johnston Gerald C, Singer Richard A
Abstract excerpt
Gene transcription is constrained by the nucleosomal nature of chromosomal DNA. This nucleosomal barrier is modulated by FACT, a conserved histone-binding heterodimer. FACT mediates transcription-linked nucleosome disassembly and also nucleosome reassembly in the wake of the RNA polymerase II transcription complex, and in this way maintains the repression of 'cryptic' promoters found within some genes. Here we...
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