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Article

Impaired cholesterol efflux in senescent macrophages promotes age-related macular degeneration.

Cell metabolism - 2 Apr 2013

Sene Abdoulaye, Khan Aslam A, Cox Douglas, Nakamura Rei E I, Santeford Andrea, Kim Bryan M, Sidhu Rohini, Onken Michael D, Harbour J William, Hagbi-Levi Shira, Chowers Itay, Edwards Peter A, Baldan Angel, Parks John S, Ory Daniel S, Apte Rajendra S

Abstract excerpt

Pathologic angiogenesis mediated by abnormally polarized macrophages plays a central role in common age-associated diseases such as atherosclerosis, cancer, and macular degeneration. Here we demonstrate that abnormal polarization in older macrophages is caused by programmatic changes that lead to reduced expression of ATP binding cassette transporter ABCA1. Downregulation of ABCA1 by microRNA-33 impairs the...

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Share to ATP Binding Cassette Transporter 1
Share to ATP Binding Cassette Transporter, Subfamily G, Member 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diet, High-Fat

Share to Endothelium, Vascular

Share to Lipoproteins

Share to Macular Degeneration

Share to Mice, Obese

Share to Neovascularization, Pathologic

Source

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Identifiers

PMID: 23562078
DOI: 10.1016/j.cmet.2013.03.009
PMCID: PMC3640261

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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