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Article

Increased Systemic and Plaque Inflammation in ABCA1 Mutation Carriers With Attenuation by Statins.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jul 2015

Bochem Andrea E, van der Valk Fleur M, Tolani Sonia, Stroes Erik S, Westerterp Marit, Tall Alan R

Abstract excerpt

OBJECTIVE: We previously demonstrated that subjects with functional ATP-binding cassette (ABC) A1 mutations have increased atherosclerosis, which has been attributed to the role of ABCA1 in reverse cholesterol transport. More recently, a proinflammatory effect of Abca1 deficiency was shown in mice, potentially contributing to atherogenesis. In this study, we investigated whether ABCA1 deficiency was associated...

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Share to Apolipoproteins B
Share to ATP-Binding Cassette Transporters

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Biological Transport

Share to Cholesterol

Share to Hydroxymethylglutaryl-CoA Reductase Inhibitors

Share to Lipoproteins

Share to Macrophages

Share to Plaque, Atherosclerotic

Source

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Identifiers

PMID: 26109739
DOI: 10.1161/ATVBAHA.114.304959
PMCID: PMC4484788

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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