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Article

microRNA-33 Regulates Macrophage Autophagy in Atherosclerosis.

Arteriosclerosis, thrombosis, and vascular biology - 1 Jun 2017

Ouimet Mireille, Ediriweera Hasini, Afonso Milessa Silva, Ramkhelawon Bhama, Singaravelu Ragunath, Liao Xianghai, Bandler Rachel C, Rahman Karishma, Fisher Edward A, Rayner Katey J, Pezacki John P, Tabas Ira, Moore Kathryn J

Abstract excerpt

OBJECTIVE: Defective autophagy in macrophages leads to pathological processes that contribute to atherosclerosis, including impaired cholesterol metabolism and defective efferocytosis. Autophagy promotes the degradation of cytoplasmic components in lysosomes and plays a key role in the catabolism of stored lipids to maintain cellular homeostasis. microRNA-33 (miR-33) is a post-transcriptional regulator of genes...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Plaque, Atherosclerotic

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Source

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Identifiers

PMID: 28428217
DOI: 10.1161/ATVBAHA.116.308916
PMCID: PMC5494696

Genes

ABCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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