Cholesterol-Induced Senescent Macrophages and Evaluation of Cellular Senescence Phenotypes.

Abstract excerpt

Recent discoveries linking cellular senescence to inflammaging and age-associated metabolic diseases have intensified interest in defining the mechanisms that drive cellular senescence. Single-cell transcriptomic studies have identified tissue-resident macrophages, long-lived and self-renewing innate immune cells, as a major reservoir of senescent cells and key contributors to age-associated chronic inflammation....

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