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Article

Targeting of miR-33 ameliorates phenotypes linked to age-related macular degeneration.

Molecular therapy : the journal of the American Society of Gene Therapy - 7 Jul 2021

Gnanaguru Gopalan, Wagschal Alexandre, Oh Justin, Saez-Torres Kahira L, Li Tong, Temel Ryan E, Kleinman Mark E, Näär Anders M, D'Amore Patricia A

Abstract excerpt

Abnormal cholesterol/lipid homeostasis is linked to neurodegenerative conditions such as age-related macular degeneration (AMD), which is a leading cause of blindness in the elderly. The most prevalent form, termed "dry" AMD, is characterized by pathological cholesterol accumulation beneath the retinal pigment epithelial (RPE) cell layer and inflammation-linked degeneration in the retina. We show here that the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33744470
DOI: 10.1016/j.ymthe.2021.03.014
PMCID: PMC8261163

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