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Article

ATP-binding cassette transporter A1 (ABCA1) in macrophages: a dual function in inflammation and lipid metabolism?

Pathobiology : journal of immunopathology, molecular and cellular biology - 1 Jan 1999

Schmitz G, Kaminski W E, Porsch-Ozcürümez M, Klucken J, Orsó E, Bodzioch M, Büchler C, Drobnik W

Abstract excerpt

Activated lipid-laden macrophages in the vascular wall are key modulators of the inflammatory processes underlying atherosclerosis. We demonstrate here that the ATP-binding cassette (ABC) transporter ABCA1 is induced during differentiation of human monocytes into macrophages. ABCA1 has been implicated in macrophage interleukin-1beta secretion and apoptosis. Moreover, ABCA1 mRNA and protein levels are strongly...

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Source

Identifiers

PMID: 10725792
DOI: 10.1159/000028100

Genes

ABCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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