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Article

Behavioral and metabolic characterization of heterozygous and homozygous POLG mutator mice.

Mitochondrion - 1 Jul 2013

Dai Ying, Kiselak Tomas, Clark Joanne, Clore Elizabeth, Zheng Kangni, Cheng Allen, Kujoth Gregory C, Prolla Tomas A, Maratos-Flier Eleftheria, Simon David K

Abstract excerpt

The mitochondrial DNA (mtDNA) polymerase γ (POLG) mutator mice provide the first experimental evidence that high levels of somatic mtDNA mutations can be functionally significant. Here we report that older homozygous, but not heterozygous, POLG mice show significant reductions in striatal dopaminergic terminals as well as deficits in motor function. However, resting oxygen consumption, heat production, mtDNA...

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Source

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Identifiers

PMID: 23542163
DOI: 10.1016/j.mito.2013.03.006
PMCID: PMC3682692

Genes

POLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Behavioral and metabolic characterization of heterozygous and homozygous POLG mutator mice.PMID 23542163Read ↗

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