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Article

Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice.

Neurotoxicology and teratology - 1 Jan 2000

Dai Ying, Clark Joanne, Zheng Kangni, Kujoth Gregory C, Prolla Tomas A, Simon David K

Abstract excerpt

Mitochondrial DNA (mtDNA) mutations are hypothesized to play a pathogenic role in aging and age-related neurodegenerative diseases such as Parkinson's disease (PD). In support of this, high levels of somatic mtDNA mutations in “POLG mutator” mice carrying a proofreading-deficient form of mtDNA polymerase ã (Polg(D257A)) lead to a premature aging phenotype. However, the relevance of this finding to the normal...

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Identifiers

PMID: 25450660
DOI: 10.1016/j.ntt.2014.10.004
PMCID: PMC4293310

Genes

POLG

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Somatic mitochondrial DNA mutations do not increase neuronal vulnerability to MPTP in young POLG mutator mice.PMID 25450660Read ↗

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Mitochondrial Respiratory Dysfunction Is Not Correlated With Mitochondrial Genotype in Premature Aging Mice.Semantic proximity Read ↗

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