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Mitochondrial Respiratory Dysfunction Is Not Correlated With Mitochondrial Genotype in Premature Aging Mice.

Aging cell - 1 Jul 2025

Tamashiro Hiroaki, Ishikawa Kaori, Sadotomo Koichi, Ogasawara Emi, Nakada Kazuto

Abstract excerpt

mtDNA mutator mice (Polgmut/mut mice) have reinforced the mitochondrial theory of aging. These mice accumulate multiple mutations in mtDNA with age due to a homozygous proofreading-deficient mutation in mtDNA polymerase gamma (Polg), resulting in mitochondrial respiratory dysfunction and premature aging phenotypes. However, whether the accumulation of multiple mutations in Polgmut/mut mice induces mitochondrial...

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Aging, Premature
DNA-Directed DNA Polymerase
DNA, Mitochondrial
DNA Polymerase gamma
Genotype

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PMID: 40318128
DOI: 10.1111/acel.70085
PMCID: PMC12266765

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