Article
Detection of mutant NPM1 mRNA in acute myeloid leukemia using custom gene expression arrays.
Genetic testing and molecular biomarkers - 1 Apr 2013
van Vliet Martin H, Dumee Belinda, Simons Erik, Bullinger Lars, Döhner Konstanze, Döhner Hartmut, Viëtor Henk, Löwenberg Bob, Valk Peter J M, van Beers Erik H
Abstract excerpt
Mutations in the gene encoding nucleophosmin (NPM1) carry a prognostic value for patients with acute myeloid leukemia (AML). Various techniques are currently being used to detect these mutations in routine molecular diagnostics. Incorporation of accurate NPM1 mutation detection on a gene expression platform would enable simultaneous detection with various other expression biomarkers. Here we present an...
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