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Article

Significance of NPM1 Gene Mutations in AML.

International journal of molecular sciences - 17 Sept 2021

Hindley Andrew, Catherwood Mark Alexander, McMullin Mary Frances, Mills Ken I

Abstract excerpt

The aim of this literature review is to examine the significance of the nucleophosmin 1 (NPM1) gene in acute myeloid leukaemia (AML). This will include analysis of the structure and normal cellular function of NPM1, the type of mutations commonly witnessed in NPM1, and the mechanism by which this influences the development and progression of AML. The importance of NPM1 mutation on prognosis and the treatment...

Topics

DNA (Cytosine-5-)-Methyltransferases
DNA Methyltransferase 3A
Humans
Leukemia, Myeloid, Acute
Mutation
Nuclear Proteins
Nucleophosmin
fms-Like Tyrosine Kinase 3

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 34576201
DOI: 10.3390/ijms221810040
PMCID: PMC8467861

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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