Article
Validation of a Multiplex mRNA- and gDNA-Based Droplet Digital PCR Assay in Acute Myeloid Leukemia Patients with an NPM1 Mutation.
Clinical chemistry - 3 Feb 2026
Wierenga Albertus T J, Hesp Lucy B, Simpelaar Arjan, Morsink Linde M, Woolthuis Carolien M, Schuringa Jan Jacob, Minovic Isidor, Huls Gerwin, Mulder André B
Abstract excerpt
BACKGROUND: NPM1 is a disease-defining gene in the diagnosis of acute myeloid leukemia (AML) and is important for measurable residual disease (MRD) assessment. Over 50 different NPM1 mutations have been described, but only the 3 most common are routinely monitored during follow-up. METHODS: We developed a multiplex droplet digital polymerase chain reaction (PCR) assay for measurement of both variant allele...
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