Article
Correlation of NPM1 immunohistochemistry with mutation subtypes, clinicopathologic variables and molecular testing in AML with NPM1 mutation.
Human pathology - 1 May 2026
Germans Sharon Koorse, Weinberg Olga K, Chen Weina, Cantu Miguel, Chen Mingyi, Oliver Dwight, Koduru Prasad, Bigham Lindsay
Abstract excerpt
BACKGROUND: Nucleophosmin 1 (NPM1) mutations define a major molecular subtype of acute myeloid leukemia (AML). Although RT-PCR and next-generation sequencing (NGS) remain the gold standard for diagnosis and minimal/measurable residual disease (MRD) assessment, NPM1 mutant-specific immunohistochemistry (NPM1m IHC) using monoclonal antibodies presents a rapid and cost-effective alternative. Correlation between...
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