Article
Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance.
Blood - 1 Dec 2005
Verhaak Roel G W, Goudswaard Chantal S, van Putten Wim, Bijl Maarten A, Sanders Mathijs A, Hugens Wendy, Uitterlinden André G, Erpelinck Claudia A J, Delwel Ruud, Löwenberg Bob, Valk Peter J M
Abstract excerpt
Mutations in nucleophosmin NPM1 are the most frequent acquired molecular abnormalities in acute myeloid leukemia (AML). We determined the NPM1 mutation status in a clinically and molecularly well-characterized patient cohort of 275 patients with newly diagnosed AML by denaturing high-performance liquid chromatography (dHPLC). We show that NPM1 mutations are significantly underrepresented in patients younger than...
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