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Article

Aldehyde dehydrogenase-2 inhibition blocks remote preconditioning in experimental and human models.

Basic research in cardiology - 1 May 2013

Contractor Hussain, Støttrup Nicolaj B, Cunnington Colin, Manlhiot Cedric, Diesch Jonathan, Ormerod Julian O M, Jensen Rebekka, Bøtker Hans Erik, Redington Andrew, Schmidt Michael R, Ashrafian Houman, Kharbanda Rajesh K

Abstract excerpt

Mitochondrial aldehyde dehydrogenase-2 (ALDH-2) is involved in preconditioning pathways, but its role in remote ischaemic preconditioning (rIPC) is unknown. We investigated its role in animal and human models of rIPC. (i) In a rabbit model of myocardial infarction, rIPC alone reduced infarct size [69 ± 5.8 % (n = 11) to 40 ± 6.5 % (n = 12), P = 0.019]. However, rIPC protection was lost after pre-treatment with...

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Identifiers

PMID: 23525499
DOI: 10.1007/s00395-013-0343-3

Genes

ALDH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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