Article
Pharmacological Activation Of Aldehyde Dehydrogenase 2 Protects Against Heatstroke-Induced Acute Lung Injury by Modulating Oxidative Stress and Endothelial Dysfunction.
Frontiers in immunology - 1 Jan 2021
Tsai Hsiao-Ya, Hsu Yu-Juei, Lu Cheng-Yo, Tsai Min-Chien, Hung Wan-Chu, Chen Po-Chuan, Wang Jen-Chun, Hsu Lung-An, Yeh Yung-Hsin, Chu Pauling, Tsai Shih-Hung
Abstract excerpt
Heatstroke (HS) can cause acute lung injury (ALI). Heat stress induces inflammation and apoptosis via reactive oxygen species (ROS) and endogenous reactive aldehydes. Endothelial dysfunction also plays a crucial role in HS-induced ALI. Aldehyde dehydrogenase 2 (ALDH2) is a mitochondrial enzyme that detoxifies aldehydes such as 4-hydroxy-2-nonenal (4-HNE) protein adducts. A single point mutation in ALDH2 at E487K...
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