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Article

Mitochondrial aldehyde dehydrogenase 2 plays protective roles in heart failure after myocardial infarction via suppression of the cytosolic JNK/p53 pathway in mice.

Journal of the American Heart Association - 18 Sept 2014

Sun Aijun, Zou Yunzeng, Wang Ping, Xu Danling, Gong Hui, Wang Shijun, Qin Yingjie, Zhang Peng, Chen Yunqin, Harada Mutsuo, Isse Toyoshi, Kawamoto Toshihiro, Fan Huizhi, Yang Pengyuan, Akazawa Hiroshi, Nagai Toshio, Takano Hiroyuki, Ping Peipei, Komuro Issei, Ge Junbo

Abstract excerpt

BACKGROUND: Increasing evidence suggests a critical role for mitochondrial aldehyde dehydrogenase 2 (ALDH2) in protection against cardiac injuries; however, the downstream cytosolic actions of this enzyme are largely undefined. METHODS AND RESULTS: Proteomic analysis identified a significant downregulation of mitochondrial ALDH2 in the heart of a rat heart failure model after myocardial infarction. The...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to JNK Mitogen-Activated Protein Kinases

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Source

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Identifiers

PMID: 25237043
DOI: 10.1161/JAHA.113.000779
PMCID: PMC4323818

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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