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Article

Variant Aldehyde Dehydrogenase 2 (ALDH2*2) Is a Risk Factor for Coronary Spasm and ST-Segment Elevation Myocardial Infarction.

Journal of the American Heart Association - 6 May 2016

Mizuno Yuji, Hokimoto Seiji, Harada Eisaku, Kinoshita Kenji, Nakagawa Kazuko, Yoshimura Michihiro, Ogawa Hisao, Yasue Hirofumi

Abstract excerpt

BACKGROUND: Mitochondrial aldehyde dehydrogenase 2 (ALDH2) plays a key role in removing toxic aldehydes. Deficient variant ALDH2*2 genotype is prevalent in up to 40% of the East Asians and reported to be associated with acute myocardial infarction (AMI). To elucidate the mechanisms underlying the association of ALDH2*2 with AMI, we compared the clinical features of AMI patients with ALDH2*2 to those with...

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Source

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Identifiers

PMID: 27153870
DOI: 10.1161/JAHA.116.003247
PMCID: PMC4889196

Genes

ALDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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