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Article

Hypertrophic preconditioning attenuates post-myocardial infarction injury through deacetylation of isocitrate dehydrogenase 2.

Acta pharmacologica Sinica - 1 Dec 2021

Ma Lei-Lei, Kong Fei-Juan, Ma Yuan-Ji, Guo Jun-Jie, Wang Shi-Jun, Dong Zheng, Sun Ai-Jun, Zou Yun-Zeng, Ge Jun-Bo

Abstract excerpt

Ischemic preconditioning induced by brief periods of coronary occlusion and reperfusion protects the heart from a subsequent prolonged ischemic insult. In this study we investigated whether a short-term nonischemic stimulation of hypertrophy renders the heart resistant to subsequent ischemic injury. Male mice were subjected to transient transverse aortic constriction (TAC) for 3 days followed aortic debanding on...

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Identifiers

PMID: 34163022
DOI: 10.1038/s41401-021-00699-0
PMCID: PMC8633015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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