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Mitochondrial Aldehyde Dehydrogenase 2 Regulates Revascularization in Chronic Ischemia: Potential Impact on the Development of Coronary Collateral Circulation.

Arteriosclerosis, thrombosis, and vascular biology - 1 Oct 2015

Liu Xiangwei, Sun Xiaolei, Liao Hua, Dong Zhen, Zhao Jingjing, Zhu Hong, Wang Peng, Shen Li, Xu Lei, Ma Xin, Shen Cheng, Fan Fan, Wang Cong, Hu Kai, Zou Yunzeng, Ge Junbo, Ren Jun, Sun Aijun

Abstract excerpt

OBJECTIVE: Revascularization is an essential process to compensate for cardiac underperfusion and, therefore, preserves cardiac function in the face of chronic ischemic injury. Recent evidence suggested a vital role of aldehyde dehydrogenase 2 (ALDH2) in cardiac protection after ischemia. This study was designed to determine whether ALDH2 regulates chronic ischemia-induced angiogenesis and to explore the...

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Source

Identifiers

PMID: 26315408
DOI: 10.1161/ATVBAHA.115.306012

Genes

ALDH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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