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Article

Inhibition of Gasdermin D by Disulfiram Attenuates Cardiac Inflammation and Fibrosis following Ischaemia Reperfusion Injury

2026-03-12

Abstract excerpt

<h4>Introduction</h4> Inadequately controlled inflammation is a key driver of adverse cardiac remodelling after acute myocardial infarction (AMI). Central to this process is activation of the NLRP3 inflammasome-gasdermin D (GSDMD) pathway, which promotes pyroptosis and the release of the pro-inflammatory cytokine interleukin-1β (IL-1β), a mediator strongly associated with infarct severity and poor clinical outcom...

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Literature Corpus work
fa933386-5466-512c-a9e1-e2d04fd1013e
DOI
10.64898/2026.03.10.710794
Open publication

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Inhibition of Gasdermin D by Disulfiram Attenuates Cardiac Inflammation and Fibrosis following Ischaemia Reperfusion InjuryDOI 10.64898/2026.03.10.710794
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