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Article

Activation of aldehyde dehydrogenase 2 (ALDH2) confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice.

Journal of molecular and cellular cardiology - 1 Apr 2010

Budas Grant R, Disatnik Marie-Hélène, Chen Che-Hong, Mochly-Rosen Daria

Abstract excerpt

Acute administration of ethanol can reduce cardiac ischemia/reperfusion injury. Previous studies demonstrated that the acute cytoprotective effect of ethanol on the myocardium is mediated by protein kinase C epsilon (PKCvarepsilon). We recently identified aldehyde dehydrogenase 2 (ALDH2) as a PKCvarepsilon substrate, whose activation is necessary and sufficient to confer cardioprotection in vivo. ALDH2...

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Identifiers

PMID: 19913552
DOI: 10.1016/j.yjmcc.2009.10.030
PMCID: PMC2837767

Genes

ALDH2

Provenance

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