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Article

SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia.

The EMBO journal - 29 May 2013

Guo Chun, Hildick Keri L, Luo Jia, Dearden Laura, Wilkinson Kevin A, Henley Jeremy M

Abstract excerpt

Global increases in small ubiquitin-like modifier (SUMO)-2/3 conjugation are a neuroprotective response to severe stress but the mechanisms and specific target proteins that determine cell survival have not been identified. Here, we demonstrate that the SUMO-2/3-specific protease SENP3 is degraded during oxygen/glucose deprivation (OGD), an in vitro model of ischaemia, via a pathway involving the unfolded protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23524851
DOI: 10.1038/emboj.2013.65
PMCID: PMC3671254

Genes

SENP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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