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Article

Redox Regulation of Mitochondrial Fission Protein Drp1 by Protein Disulfide Isomerase Limits Endothelial Senescence.

Cell reports - 19 Jun 2018

Kim Young-Mee, Youn Seock-Won, Sudhahar Varadarajan, Das Archita, Chandhri Reyhaan, Cuervo Grajal Henar, Kweon Junghun, Leanhart Silvia, He Lianying, Toth Peter T, Kitajewski Jan, Rehman Jalees, Yoon Yisang, Cho Jaehyung, Fukai Tohru, Ushio-Fukai Masuko

Abstract excerpt

Mitochondrial dynamics are tightly controlled by fusion and fission, and their dysregulation and excess reactive oxygen species (ROS) contribute to endothelial cell (EC) dysfunction. How redox signals regulate coupling between mitochondrial dynamics and endothelial (dys)function remains unknown. Here, we identify protein disulfide isomerase A1 (PDIA1) as a thiol reductase for the mitochondrial fission protein...

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Source

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Identifiers

PMID: 29924999
DOI: 10.1016/j.celrep.2018.05.054
PMCID: PMC6324937

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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