Article
Enhanced SUMOylation and SENP-1 protein levels following oxygen and glucose deprivation in neurones.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Jan 2012
Cimarosti Helena, Ashikaga Emi, Jaafari Nadia, Dearden Laura, Rubin Philip, Wilkinson Kevin A, Henley Jeremy M
Abstract excerpt
Here, we show that oxygen and glucose deprivation (OGD) causes increased small ubiquitin-like modifier (SUMO)-1 and SUMO-2/3 conjugation to substrate proteins in cultured hippocampal neurones. Surprisingly, the SUMO protease SENP-1, which removes SUMO from conjugated proteins, was also increased by OGD, suggesting that the neuronal response to OGD involves a complex interplay between SUMOylation and...
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