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Article

1-Deoxydihydroceramide causes anoxic death by impairing chaperonin-mediated protein folding.

Nature metabolism - 1 Oct 2019

Hannich J Thomas, Haribowo A Galih, Gentina Sébastien, Paillard Melanie, Gomez Ludovic, Pillot Bruno, Thibault Hélène, Abegg Daniel, Guex Nicolas, Zumbuehl Andreas, Adibekian Alexander, Ovize Michel, Martinou Jean-Claude, Riezman Howard

Abstract excerpt

Ischaemic heart disease and stroke are the most common causes of death worldwide. Anoxia, defined as the lack of oxygen, is commonly seen in both these pathologies and triggers profound metabolic and cellular changes. Sphingolipids have been implicated in anoxia injury, but the pathomechanism is unknown. Here we show that anoxia-associated injury causes accumulation of the non-canonical sphingolipid...

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PMID: 32694842
DOI: 10.1038/s42255-019-0123-y

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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