Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Global Protein Conjugation by Ubiquitin-Like-Modifiers during Ischemic Stress Is Regulated by MicroRNAs and Confers Robust Tolerance to Ischemia

18 Oct 2012

Abstract excerpt

Hibernation torpor provides an excellent model of natural tolerance to ischemia. We have previously shown that massive global SUMOylation occurs during hibernation torpor in ground squirrels. We have also shown that overexpression of Ubc9, SUMO-1, or SUMO-2/3 provides protection against ischemic damage in cell lines and cortical neurons exposed to oxygen/glucose deprivation, and in mice exposed to middle cerebral...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autophagy in Disease and Therapy
Share to Toxoplasma gondii Research Studies
Share to Ubiquitin and proteasome pathways

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23094087
DOI: 10.1371/journal.pone.0047787

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Global Protein Conjugation by Ubiquitin-Like-Modifiers during Ischemic Stress Is Regulated by MicroRNAs and Confers Robust Tolerance to IschemiaPMID 23094087Read ↗

Elevated global SUMOylation in Ubc9 transgenic mice protects their brains against focal cerebral ischemic damage.Semantic proximity Read ↗

Enhanced SUMOylation and SENP-1 protein levels following oxygen and glucose deprivation in neurones.Semantic proximity Read ↗

Mammalian hibernation: differential gene expression and novel application of epigenetic controlsSemantic proximity Read ↗

Ubiquitous regulation of cerebrovascular diseases by ubiquitin‐modifying enzymesSemantic proximity Read ↗

SUMO proteomics to decipher the SUMO‐modified proteome regulated by various diseasesSemantic proximity Read ↗

SUMOylation as a Therapeutic Target for Myocardial InfarctionSemantic proximity Read ↗

Proteomic analysis of ubiquitination modified proteins in brain tissue of rats at different times after severe traumatic brain injurySemantic proximity Read ↗

HDAC2 Selectively Regulates FOXO3a-Mediated Gene Transcription during Oxidative Stress-Induced Neuronal Cell DeathSemantic proximity Read ↗

Genetic screen identified PRMT5 as a neuroprotection target against cerebral ischemia.Semantic proximity Read ↗

Characterization of a novel posttranslational modification in neuronal nitric oxide synthase by small ubiquitin-related modifier-1.Semantic proximity Read ↗

Role of ubiquitin carboxy terminal hydrolase-L1 in neural cell apoptosis induced by ischemic retinal injury in vivo.Semantic proximity Read ↗

SENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.