Article

Astrocytic glycogen aggregates induce ATAD3A oligomerization mediated mitochondrial fragmentation and impede stroke recovery

2026-02-03

Abstract excerpt

<title>Abstract</title> <p>Ischemic stroke induces pathological glycogen deposition in astrocytes, but its role in post-injury neural dysfunction remains undefined. We reveal that glycogen-laden astrocytes in the ischemic penumbra undergo ATAD3A-dependent mitochondrial fragmentation via a stress granule-mediated mechanism, exacerbating neuronal injury and hindering functional recovery. Mechanistic studies demonst...

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Literature Corpus work: dd14d711-62f9-53e8-9270-33818ab711df
DOI: 10.21203/rs.3.rs-6650856/v1

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Astrocytic glycogen aggregates induce ATAD3A oligomerization mediated mitochondrial fragmentation and impede stroke recoveryDOI 10.21203/rs.3.rs-6650856/v1Read

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