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Article

SOK1 translocates from the Golgi to the nucleus upon chemical anoxia and induces apoptotic cell death.

The Journal of biological chemistry - 6 Jun 2008

Nogueira Emilio, Fidalgo Miguel, Molnar Arpad, Kyriakis John, Force Thomas, Zalvide Juan, Pombo Celia M

Abstract excerpt

SOK1 is a Ste20 protein kinase of the germinal center kinase (GCK) family that has been shown to be activated by oxidant stress and chemical anoxia, a cell culture model of ischemia. More recently, it has been shown to be localized to the Golgi apparatus, where it functions in a signaling pathway required for cell migration and polarization. Herein, we demonstrate that SOK1 regulates cell death after chemical...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18364353
DOI: 10.1074/jbc.M709724200
PMCID: PMC2414289

Genes

GCK

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