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Myeloid DRP1 Sulfenylation Drives Reparative Macrophage Polarization and Neovascularization in Ischemic Muscle

2026-02-17

Abstract excerpt

Reparative macrophage polarization and macrophage-derived reactive oxygen species (ROS) are required for ischemia-induced revascularization in peripheral artery disease (PAD). Our previous study showed that mitochondrial fission protein DRP1 promotes reparative polarization and metabolic reprogramming in macrophages and post-ischemic neovascularization. However, the redox-dependent mechanism governing DRP1 activat...

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Literature Corpus work
35b0af59-ce2c-5122-b2a7-857b2241fbc2
DOI
10.64898/2026.02.15.706043
Open publication

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Myeloid DRP1 Sulfenylation Drives Reparative Macrophage Polarization and Neovascularization in Ischemic MuscleDOI 10.64898/2026.02.15.706043
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