Article
Down-regulation of parkin protein in transient focal cerebral ischemia: A link between stroke and degenerative disease?
1 Nov 2002
Abstract excerpt
Ubiquitylated protein aggregates are characteristic features of neurodegenerative disorders that are also found in acute pathological states of the brain such as stroke. Many of the proteins connected to neurodegenerative diseases play a role in the ubiquitin-proteasomal pathway. Mutation of one of these proteins, the E3 ubiquitin ligase parkin, is the cause of autosomal recessive juvenile Parkinson's disease....
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